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Prof. Fiorenzo Vetrone

Institut National de la Recherche Scientifique - Énergie, Matériaux et Télécommunications, Université du Québec, Varennes, QC, Canada

Friday, October 14th, 2011 at 02:30:00 PM

Classroom 1 of Building F within AREA CNR - Via Madonna del Piano 10, Sesto Fiorentino (Florence)

Published on-line at 12:55:44 PM on Monday, October 10th, 2011

Upconverting nanoparticles: from basic synthesis to applications in imaging and diagnostics

Multi-photon excited luminescent nanomaterials are useful tools in diagnostic medicine: lanthanide nanoparticles seem to be a good candidate for these purposes.

Multi-photon excited luminescent nanomaterials are emerging as useful tools in diagnostic medicine and therapeutics. These nanomaterials are excited with near-infrared (NIR) light, which is silent to tissues thus minimizing autofluorescence, possesses greater tissue penetration capabilities and does not cause damage to the sample. Moreover, these nanomaterials require femtosecond (fs) excitation light to induce the multi-photon excited luminescence, which results in increased spatial resolution. An alternative to multi-photon excited nanomaterials is lanthanide (Ln3+)-doped upconverting nanoparticles, which have the ability to (up)convert NIR light to higher energies spanning the UV to the NIR. This occurs via the process of upconversion resulting from the multitude of Ln3+ electronic energy states, many of which are equally spaced leading to the sequential absorption of multiple NIR photons. These energy states are long-lived eliminating the need for fs laser excitation and thus, upconversion can be observed following excitation with low energy cw NIR diode lasers. In contrast, other multi-photon excited nanomaterials require the simultaneous absorption of photons from ultrafast fs lasers.

Here, we present the synthesis of upconverting Ln3+-doped fluoride nanoparticles and show how these nanoparticles could be used as multi-functional bioprobes for imaging and nanothermometry of malignant cancer cells.

For further informations, please contact Dr. Roberto Pini.