Dr. Alessandro Gozzi
Monday, December 12th, 2011 at 03:30:00 PM
Conference room Querzoli - LENS - via Nello Carrara 1 - Sesto Fiorentino (Florence)
Published on-line at 05:13:59 PM on Tuesday, December 6th, 2011
Mapping altered neurofunctional states with multiparametric Magnetic Resonance Imaging
How the combined use of functional, pharmacological and morpho-anatomic MRI led to the identification of altered functional and neuroanatomical substrates.
The development of functional Magnetic Resonance Imaging (fMRI) has made possible the investigation of brain function with unprecedented spatio-temporal resolution. Whilst primarily designed for human investigations, there exists significant scope for the application of these methods in pre-clinical species. When combined with state-of-the-art morphometric measurements, these techniques may provide a system-view description of the neuro-functional architecture of the brain in health and disease, thus greatly enhancing the assessment of construct- and predictive-validity of preclinical models of CNS pathology.
In this talk we will show how the combined use of functional, pharmacological and morpho-anatomic MRI led to the identification of a series of altered functional and neuroanatomical substrates in animal models of drug addiction that closely mimic hallmark neuroimaging findings in human addicts.
Our findings support the translational value of multiparametric MRI approaches to investigate the neuro-biological substrates underlying the behavioral expression of CNS pathologies in laboratory animals.
For further informations, please contact Prof. Francesco Pavone.
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